This image begins a week of views of the city of Laramie, Wyoming. A photo on the linked page shows that at least some of the buildings depicted here are still standing at the present date.
Second Street and Business District – Laramie, Wyo.
The small sign on the pole in the right foreground indicates this was US Highway 287 when the picture was taken, but that highway now proceeds along 3rd Street.
This card dates from a time when no descriptions were printed on the back, only guides indicating where to write the address and the message. The cars and trucks indicate this image is from the 1940s.