This is a color illustration of one of the main streets in Indianapolis, Indiana. This earlier image shows the same building fourth down from the left, indicating this is the corner of Washington and Illinois Street.
There is no description on the back of the card. This is likely taken from a black and white photo, retouched and colored, rather than from a completely hand-drawn image.
This card was used and is dated 8 August 1951, but the image likely dates from the 1940s.