This is a view down Powell Street, the cross street in the foreground is Bush, as indicated by the street sign in the lower left. The view is towards Union Square, visible in the background.
The description states:
BUSY CABLE CARS climb the steep, terraced Powell Street Hill at twilight time. San Francisco, California.
–The sign in the distance for the Manx Hotel is at the corner of Powell and O’Farrell. The building is still a hotel, but is now the Villa Florence. The cars shown indicate this card is from the 1960s.